0704-883-0675     |      dataprojectng@gmail.com

EVALUATION OF BIOACTIVE METABOLITE CONTENTS, MOSQUITO LARVICIDAL AND ANTI-PLASMODIAL ACTIVITIES OF EXTRACTS OF THE SPIDER Neoscona adianta

  • Project Research
  • 1-5 Chapters
  • Abstract : Available
  • Table of Content: Available
  • Reference Style: APA
  • Recommended for : Student Researchers
  • NGN 3000

ABSTRACT

In spite of the extensive control efforts, over the years, mosquito still transmit serious human diseases, cause millions of deaths every year and the development of resistance to chemical insecticides resulting in rebounding vectorial capacity. This situation is aggravated with the re-emergence of drug resistance of mosquito borne diseases especially malaria. The current study was therefore designed to assess the mosquito larvicidal potency and antiplasmodial efficacy of the crude and fractions of the extract of the spider (Neoscona adianta). The zoochemical components of the crude and fractions of the spider extracts were assessed following standard procedures. The larvicidal potency of the crude and fractions of the spider was carried out according to World Health Organization (WHO) standard protocol with slight modifications. Graded concentrations (ranging from 0.2 to 2.0 mg/k) of the crude and fractions of the spider extracts were tested against 25 batches of healthy 4th instar larvae of Culex mosquito species, and larval mortality was recorded after 24 hours exposure period. Acute oral toxicity of the crude extract was carried out to establish the oral safe dose. The antiplasmodial activates of the crude extract and fractions were bio-assayed against established infection in chloroquine-sensitive Plasmodium berghei infected mice. The results indicated the presence of zoochemicals including flavonoid, tannins, saponnins, alkaloids steroids total phenol and terpeniods in the crude extract and fractions of the spider. The results of the larvicidal bio-assay revealed that both crude and fractions showed a dose and concentration-dependent larvicidal potency. Larvicidal activities was significantly higher (P<0.05) in the ethylacetate and n-henane fractions than in the crude methanol extract. Similarly, only the ethylacetate and n-hexane recorded 100% mortality for the highest concentration tested (2.0 mg/h). The best larvicidal activity was found in the nhexane fraction with an LC50 of 0.46mh/L, followed by ethylacetate with LC50 of 0.94mg/L. The results of the acute oral toxicity revealed that the spider extract is safe for oral administration with an LC50 greater than 5000mg/kg body weight. The crude and fractions of the spider extract showed a dose dependent antiplasmodial activities with peak activity recorded of the group of mice treated with 600mg/kg b.wt crude extract. The crude and fractions did not ameliorate fall in PCV but promoted body weight change and elongated the survival time. The results support the medicinal use of spider extracts in folkloric medicine and suggest that this spider contained bio-active compounds that could be developed as potent antimalarial drug as well as potent bio-pesticide agent against mosquito vector.





Related Project Materials

EFFECTS OF NON COMPUTERIZATION OF PATIENT'S RECORDS IN SELECTED RURAL HOSPITALS IN JEMA'A LOCAL GOVERNMENT AREA, KADUNA STATE

Abstract

Health record management practice is imperative in any health service providing institution in ensuring qualit...

Read more
THE EFFECT OF THE STUDY ENVIRONMENT AND THE PERFORMANCE OF SECRETERIAL STUDENTS

Background Of The Study

Over the year, it has been observed that environmental forces pose a great infl...

Read more
ECONOMIC ANALYSIS OF PIG PRODUCTION

Background of the Stud...

Read more
FRAUD IN THE NIGERIAN BANKING INDUSTRY: CAUSES, CONSEQUENCES AND SOLUTION

ABSTRACT

This research work was designed to study fraud in the Nigerian banking industry. This study ti...

Read more
AN ASSESSMENT OF THE ROLE AND CHALLENGES OF NON GOVERNMENTAL ORGANISATIONS IN RURAL DEVELOPMENT IN NIGERIA

STATEMENT OF THE PROBLEM

Rural development is a comprehensive concept which addresses the general problems that militate...

Read more
THE CONTRIBUTION OF BANK OF INDUSTRY (BOI) TO INDUSTRIAL DEVELOPMENT IN NIGERIA (1980-2010)

BACKGROUND OF THE STUDY

Industrial financing organizations have undergone a structural transformation during the last three decades in mo...

Read more
FINANCIAL PLANNING AND CONTROL IN MEDIA OUTFIT

Background to the Study

The attainment of corporate objectives is a function of the prudent use of committed economic r...

Read more
Computer information system Development of mobile application for hotel reservation and Other services for foreigners in Sudan

Abstract

Information technology has expanded rapidly over the years as a result of fast growth of science and technology. Developing succ...

Read more
EFFECTS OF COVID-19 ON PRODUCT SALES AND MARKETING

ABSTRACT

This study titled the effect of covid-19 on product sales and marketing aims to find out the i...

Read more
THE EFFECT OF SINGLE PARENTING CHILD UPBRINGING ON SCHOOL CHILDREN: CASE STUDY OF SOME SELECTED INDIVIDUALS IN IKAOKHA LOCAL GOVERNMENT AREA, AKWA IBOM STATE, NIGERIA

 BACKGROUND TO THE STUDY

Nurturing and upbringing of a child by parents in the society is a realit...

Read more
Share this page with your friends




whatsapp